Product Description

Vinblastine Subjects		Vinblastine Specifications	Results
Characters	Appearance	White or almost white powder	White powder
	Solubility	Freely soluble in water and in methanol , practically insoluble in hexane	Conform
Identification	A. Infrared Absorption	ir spectrum of the sample corresponds to that of the ref standard	Conform
	B.HPLC	The retention time of the major peak in the chromatograms corresponds to that in the reference standard	Conform
	c. Tartrate Reaction	Positive for tartrate	Conform
Test	Clarity of solution	Clear solution(140mg/10ml water)	Clear solution
	Color of solution	Absorbance at 420nm NMT0.03 (1.4%W/V solution in water)	0.003
	PH	3.3~3.8	3.5
	Water	Not more than 4.0%	2.3%
	Residue on ignition	Not more than 0.1	Conform
	Heavy metals	Not more than 20ppm	NMT 10ppm
	Boron	Not more than 50ppm	Conform
	Fluorides	Not more than 50ppm	Conform
	Silver	Not more than 5ppm	Conform
Related Compounds	Impurity A	Not more than 0.3%	0.04%
	Any other impurity	Not more than 0.2%	0.10%
	Sum of impurities other than A	Not more than 0.7%	0.23%
Residual Organic solvent	Chloroform	Not more than 0.005%	0.003%
	Methylence Chloride	Not more than 0.01%	0.004%
	Acetone	Not more than 0.5%	0.33%

Ether	Not more than 0.5%	0.05%
Methanol	Not more than 0.3%	0.06%
Hexance	Not more than 0.029%	0.008%
Tetrahdrofuran	Not more than 0.072%	0.011%
Bacterial endotoxins	Not more than 2EU/mg	Conform
Microbiological purity( bactenas and mould)	Not more than 100 CFU/g	Conform
Enterobacteriaceae	Not detected	Not detected
Pseudomonas aeruginosa	Not detected	Not detected
Staphylococcus aureus	Not detected	Not detected
Assay	98.0%~102.0%(On the anhydrous basis)	99.8%
Conclusion	All standards comply with EP6.0

Description

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Indication	For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Pharmacodynamics	Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Mechanism of action	The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Protein binding	98-99%

State	solid
Experimental Properties	PropertyValue melting point 267 °C water solubility Negligible logP 3.70
Predicted Properties	PropertyValue water solubility 1.69e-02 g/l logP 4.22 logP 4.18 logS -4.7 pKa (strongest acidic) 10.87 pKa (strongest basic) 8.86 physiological charge 2 hydrogen acceptor count 9 hydrogen donor count 3 polar surface area 154.1 rotatable bond count 10 refractivity 222.42 polarizability

Packaging & Shipping

25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients

Our Services

1. A full refund will be guranteed if you dissatisfy our products .

2. 24/7 online service for your inquiries.

3. Free sample.

4. worldwide fastest delivery as soon as you pay.

Company Information

Founded in 2003 as a professional international pharmaceutical corporation, headquartered in Xi'an (China), Shaanxi Pioneer Biotech Co., Ltd. is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Shaanxi Pioneer Biotech Co., Ltd. manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP,HACCP norms, international Pharmacopoeias, and international regulations.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium;These items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Pioneer has been working hard on the research and development of new slimming and male enhancement ingredients we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

Contact Us

Bin Cheng

Sales Manager

Shaanxi Pioneer Biotech Co., Ltd

Add:No.11 Daqing Road, Xi'an, Shaanxi, China 710082

Tel:86-029-87318523 86-18392545405

Fax:029-84385017