Guanidinium chloride is a strong chaotrope and one of the strongest denaturants used in physiochemical studies of protein folding. At high concentrations of guanidinium chloride (e.g., 6 Molar), proteins lose their ordered structure, and they tend to become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, guanidinium chloride has been shown to "cure" prion positive cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative phenotype). This is the result of inhibition of the Hsp104 chaperone protein known to play an important role in prion fiber fragmentation and propagation

SHANGHAI YUNG ZIP PHARM. TRADING CO., LTD.

SHANGHAI YUNG ZIP PHARM. TRADING CO., LTD is a sole proprietorship which is set up in the economic center of mainland China by the largest pharmaceutical company of YUNG SHIN PHARM.IND.CO.,LTD in Taiwan. SHANGHAI YUNG ZIP PHARM. TRADING CO., LTD Founded on December 10, 1994, registered addresses in the Waigaoqiao Free Trade Zone Pudong, registered capital is USD 4 million,Main business areas including international trade, inter-enterprise trade and bonded within the agency, local storage and simple processing.